Cystic fibrosis Essay Example | Topics and Well Written Essays - 2500 words

Cystic fibrosis - Essay Example It is possible that several hundred different mutations of the gene exist than can cause cystic fibrosis. The gene was discovered in 1989. The underlying defect stems from a mutation in a gene on the long arm (q) of chromosome 7. The protein product acts as a chloride channel. It is called the cystic fibrosis trans membrane conductance regulator (CFTR). This controls the cellular transport of sodium chloride and water. It is inherited and is a recessive gene. Some may be unique to certain families so testing of families in which the disease is present may yield results that will help to determine the specific mutation. People having this disease in the past were not expected to live long enough to reach adulthood but improved diagnoses and treatment now allows them to live even beyond fifty years of age. The usual form of death is from respiratory failure. In normal people chloride the chloride and sodium that is presented in sweat are reabsorbed by epithelial cells in the sweat dust as the sweat finds its way to the surface of the skin. In people with cystic fibrosis the defective gene inhibits the reabsorbing of chloride and sodium ions resulting in an excess of sodium chloride or very salty sweat. In normal people, the function of respiratory tract epithelial cells is to transport chloride ions into the lumen thereby maintaining the adequate hydration of mucus. In the respiratory tract of persons with cystic fibrosis there is a reduction of the secretion of sodium ions and water caused from the inability of epithelial cell membranes to influence the hydration of mucus. Consequently the mucus becomes very thick. This mucus affects the clearance of irritation and micro-organisms from the lungs. The following events occur in the lungs. Genetic testing is now available. Cells are collected from inside the cheek of patients and then examined for the

Consulting in Business Analysis Personal Statement

Consulting in Business Analysis - Personal Statement Example I need to understand how businesses work around the globe and how environmental changes have their ever increasing impact on them. Recent financial turmoil introduced me to concepts like coupling of economies, of which I could only make out that it’s the way performance of one economy is linked with the performance of other economies, and how did this overall series of events in America actually influence job scenario for people working in India or China was beyond my perspective. But that did intrigue me to explore further on how this would have influenced my business and my life, so in future when I will plan for my business I should be able to understand that what all such events would portend for me. But apart from quenching this curiosity, the overarching objective was to set up my own business after 5-6 years of corporate experience within my preferred industry. So the obvious choice where all these issues seemed to converge was an MBA degree from a reputed university bu t as most of such universities look for some experience so job eligibility before MBA became the midterm objective and for that, I would have needed a graduate degree in business management. The foundation course figured as a short run objective for that. If I were to spell out my exact expectations from the course then I must admit that I did not have much idea about it. I knew only one thing that it would act as a bridge to my future studies and as a student, my objective from this course was more or less passing with good grades. But the objective did not remain just what it was before joining the course, as exposure to seminars, book reading, assignments, portfolio all changed my thoughts. My preoccupation with just marks waned and other important aspects of attending the course started surfacing.